Rasaratnasamuccaya consists of 30 chapters. In the first eleven chapters various medicinal substances with their classifications have been described from all angles along with information about various accessories required. In the first chapter Mercury along with its properties and origin, types etc. have been described. Sixth, seventh and eighth chapter are important as they describe teacher and students of Rasasastra, construction of manufacturing unit and terminologies of Rasasastra. Ninth and tenth chapters are meant for various equipments and fireplaces and their construction and uses. Eleventh chapter describes various units of measurements and various processes to which mercury is subjected. The author himself has accepted that all this information is compiled from other treatise like Rasarnava etc.
Acharya Vagbhata has mentioned a verse about Druti(Ayurveda Rasashastra formulation which generally is prepared from Gandhak(sulphur) from Acharya Somadeva description of Druti which mentions that without the blessings of Lord Sankara, Druti preparation is impossible. Eventhough this verse is quoted, still many methods of Druti preparation are compiled in this treatise.